| 04-May-1935 | 16-Mar-1936 | William H. Hornibrook |
| 19-May-1941 | 25-Jul-1942 | Louis G. Dreyfus, Jr. |
| 02-Jul-1942 | 17-Aug-1945 | Cornelius Van H. Engert |
| 06-Dec-1945 | 18-Nov-1948 | Ely E. Palmer |
| 16-Aug-1949 | 19-Jan-1951 | Louis G. Dreyfus, Jr. |
| 28-Jun-1951 | 03-May-1952 | George R. Merrell |
| 08-Nov-1952 | 03-Mar-1956 | Angus Ward |
| 06-May-1956 | 03-Feb-1959 | Sheldon T. Mills |
| 21-Mar-1959 | 19-Jan-1962 | Henry A. Byroade |
| 20-Mar-1962 | 21-Jul-1966 | John M. Steeves |
| 19-Feb-1967 | 10-Sep-1973 | Robert G. Neumann |
| 21-Nov-1973 | 14-Jun-1978 | Theodore L. Eliot, Jr. |
| 12-Jul-1978 | 14-Feb-1979 | Adolph Dubs (Assassinated) |
| Feb-1979 | Feb-1980 | J. Bruce Amstutz (Interim) |
| Feb-1980 | Jan-1982 | Hawthorne Q. Mills (Interim) |
| Jan-1982 | May-1983 | Charles F. Dunbar (Interim) |
| Jun-1983 | Mar-1986 | Edward Hurwitz (Interim) |
| Mar-1986 | Sep-1987 | James M. Ealum (Interim) |
| Sep-1987 | Jan-1989 | John D. Glassman (Interim) |
| Embassy in Kabul closed 30-Jan-1989 |
| Liaison Office in Kabul reopened 17-Dec-2001 |
| 02-Jan-2002 | Apr-2002 | Ryan C. Crocker (Interim) |
| 03-Apr-2002 | 01-Aug-2003 | Robert Finn |
| 28-Nov-2003 | 20-Jun-2005 | Zalmay Khalilzad |
| 01-Aug-2005 | 02-Mar-2007 | Ronald E. Neumann |
| 16-Apr-2007 | 03-Apr-2009 | William B. Wood |
| 29-Apr-2009 | | present Karl W. Eikenberry[*] |
